CynapseDx has developed prototype assays that can measure the oligomeric and aggregated forms (if present) of ß-amyloid, α-synuclein and phospho-tau in blood. The assays have been tested on blood samples from patients with Alzheimer’s Disease, Parkinson’s Disease and Dementia with Lewy Bodies. Some example data are shown below.
We are currently recruiting samples for more Parkinson’s and non-Parkinson’s tremor patients to show that the mis-diagnosed patients can be identified to avoid wasted treatment costs. This study is expected be completed by end 2016.
We are also recruiting samples from healthy controls across a range of ages to determine whether there is evidence of age related build-up of the aggregated forms of all 3 proteins.
Results on measurement of ß-amyloid and α-synuclein in real blood samples from patients with Alzheimer’s disease, Parkinson’s disease and Dementia with Lewy Bodies compared to healthy controls under the age of 30 and 2 spouses.